How do I:
Komodo keeps user preferences, a code intelligence database, and a number of other files in a user data directory. It's location on various platforms is described here:
http://docs.activestate.com/komodo/4.4/trouble.html#appdata_dir
Sometimes files in this directory can become corrupted, causing problems running Komodo. If this problem can't be tracked down to a particular file in the user data directory, there is a nuclear option:
Komodo will generate a fresh user data directory.
If you have preferences or a Toolbox you want to keep, move or rename the directory (e.g. "4.4-corrupt") instead of deleting it. You can then try moving some of the files (e.g. prefs.xml or toolbox.kpf) from the original directory back into the fresh user data directory.